Gout is an inflammatory arthritis associated with hyperuricemia leading to deposition of monosodium urate crystals in the joints. It is more common in men than in women, women become susceptible to it after menopause, it is usually asymptomatic before the age of 30.
Gout has four stages:
Gout is produced as a result of hyperuricemia when excessive amounts of uric acid (an end product of purine metabolism), accumulate within several tissues specially the joints as a result of defects in purine metabolism. This accumulation induce an acute inflammatory reaction.
Although a high level of uric acid is an essential component of gout, not all such persons develop gout, sometimes genetic and environmental factors also contribute to its pathogenesis.
Gout usually begins at night as an acute attack appears suddenly other symptoms often includes:
Gout risk factors include:
Coffee, folate and dairy products intake lowers gout risk. Avoiding medications that causes hyperuricemia like thiazide diuretics, cyclosporine and aspirin.
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Along with medications, lifestyle changes may help manage the symptoms and reduce risk of gout attacks.
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