Proton Pump Inhibitors (PPIs) are a class of drugs that are used in the treatment of heartburn, gastric ulcers and various acid related disorders. They work by decreasing gastric acid production.
List of PPI drugs:
Examples of available PPI medications include:
*Note: All the generic names of this drug class end in the suffix “prazole”.
In the stomach there is an enzyme system that regulates and causes acid secretion by the cells lining the stomach, this system is also known as (proton pump). This system will facilitate acid secretion by transporting hydrogen ions into the stomach.
Proton pump inhibitors act by reducing gastric acid production by blocking hydrogen- potassium and adenosine triphosphate enzyme system (the proton pump) of the parietal cells.
Generally, proton pump inhibitors are used in the prevention and treatment of various gastric disorders, including:
►Gastroesophageal reflux disease (GERD)
►Dyspepsia (indigestion)
►Zollinger-Ellison syndrome
►Duodenal ulcers
►NSAIDs associated gastric ulcers
►Helicobacter pylori infection
These drugs may cause some unwanted effects. Common side effects caused by proton pump inhibitors include:
- Abdominal pain
- Diarrhea
- Constipation
- Vomiting
- Nausea
- Dry mouth
- Headache
- Hyperglycemia
Uncommon and rare side effects may include:
- Hallucination
- Confusion
- Vertigo
- Gynecomastia (enlargement of the breast tissue in men)
- Liver disorders
Patients with the following conditions should consult a doctor before using any of these drugs:
PPI drugs can form drug-drug interactions with the following medications:
- Antifungals
- Clopidogrel
- Diazepam
- Digoxin
- Hypomagnesemia-causing drugs
- Iron supplements
- Phenytoin
- Sucralfate
- Tacrolimus
- Theophylline
1. Kizior, R.J. and Hodgson, B.B. (2018). Saunders nursing drug handbook 2019. Philadelphia: Saunders.
2. British Medical Association (2015). British Medical Association new guide to medicine & drugs. London: Dorling Kindersley
3. Joint formulary committee, BNF 80 (The British National Formulary), 80th revised edition, Pharmaceutical Press, London, United Kingdom, [2020]
4. Winter, H., Moore, S.W., Boesen, K. and Boesen, C. (2017). Complete guide to prescription & nonprescription drugs, 2018-2019. New York: Tarcherperigee, An Imprint Of Penguin Random House Llc.
The urethra is a muscular canal that extends from the neck of the bladder to the exterior of body. Read more about the anatomy of urethra in this article.
UTI in men tends to be less common compared to women due to the anatomical differences, (the length of the urethra is 20 cm in men in but 5 cm in women)
Learn about medical uses, safety profile, mechanisms and interactions of statins.
Comprehensive guide on Ozempic (semaglutide), including its uses, dosage, side effects, warnings, and interactions.
.png)
Subscribe to our email lists and upgrade your life into a healthier and happier one.
SubscribeSign up for our newsletter(s) and receive healthy and scientific content to have a healthier life.
Choose Newsletter(s)Follow Medical Hex on social media platforms to be informed about latest health news and health-related scientific concepts.
A place you can find correct medical advice and information on health conditions as well as medical scientific articles. Our aim is to improve the health of human race by increasing health literacy through providing science-based content about health conditions.
©2022 Medical Hex. All Rights Reserved.
Choose what we can use. Strictly necessary and security cookies are always on.