In addition to diet and exercise, glimepiride is used to lower glucose levels in patients with type 2 diabetes whose hyperglycemia cannot be controlled with diet and exercise alone.

Adults: 1 or 2 mg P.O. once daily at first; usual maintenance dose is 1 to 4 mg P.O. once daily. After reaching 2 mg, the dosage is increased in 2 mg increments every 1 to 2 weeks, based on the patient's glucose level response. The daily maximum dose is 8 mg.

Adjunct to diet and exercise in combination with insulin or metformin therapy in patients with type 2 diabetes whose hyperglycemia cannot be controlled with the maximum glimepiride dosage alone.

Adults: 8 mg P.O. once daily; used in conjunction with low-dose insulin. If necessary, increase insulin dosage every week based on the patient's glucose level response. Alternatively, if patients do not respond adequately to the maximum dose of glimepiride, metformin may be added.

Dose cautiously in elderly, debilitated, or malnourished patients, and those with renal or hepatic impairment:

(Adjust-a-dose) For patients with renal or hepatic impairment, start with 1 mg P.O. once daily and gradually increase to the appropriate dosage if necessary.

Patients with renal or hepatic impairment; patients who are elderly, debilitated, or malnourished; patients who have adrenal or pituitary insufficiency:

The typical starting dose is 1 mg PO once daily; however, lower maintenance doses may be sufficient to control blood sugar.

Pediatric patients:

Safety and efficacy are still to be established.

Monitor serum glucose levels regularly to determine the efficacy of the drug and the dosage being used.

-During times of high stress, switch to insulin therapy (eg, infections, surgery, trauma).

-If severe hypoglycemia occurs as a result of an overdose, administer IV glucose.

-Make an appointment with a dietitian to develop a weight-loss plan and a dietary plan control.

-Arrange for a comprehensive diabetic education program that covers disease, dietary control, exercise, signs, and symptoms of hypoglycemia and hyperglycemia, infection prevention, and hygiene.

-If the patient's response is inadequate, consider adding metformin to the drug regimen; closely monitor the patient.

-Take this medication once a day with breakfast or the first main meal of the day

- Do not stop taking it without first consulting your health care provider.

-Maintain your diabetes-controlling diet and exercise routine.

-Glucose levels in the blood should be checked regularly, as directed.

-If you are pregnant, do not take this medication.

-Avoid consuming alcohol while using this medication.