Enalapril (Vasotec) is an Antihypertensive agent that belongs to a class of drugs known as angiotensin-converting enzyme inhibitors (ACE-inhibitors). Enalapril is rapidly converted to its active metabolite, Enalaprilat, by hepatic biotransformation.
This agent is a vasodilator that is used to treat high blood pressure and heart failure. Enalapril is sold under the brand name Vasotec, it is available as oral tablets, powder for oral solution and injection solution.
Maleate salt of Enalapril is called Enalapril maleate, it is also available as combinations with diuretics such as:
Enalapril maleate/ hydrochlorothiazide (available as the brand name Vaseretic)
Enalapril (Vasotec) is used in the treatment of:
- Hypertension (high blood pressure)
- Symptomatic heart failure
- Asymptomatic left ventricular disorder
Enalapril (Vasotec) is available as:
- Tablets: 2.5 mg, 5 mg, 10 mg, 20 mg
- Injection solution: 1.25 mg/mL
- Powder for oral Solution: 1 mg/mL
Hypertension
Adults and Elderly:
Oral: Initially 2.5mg/day (if the patient is taking diuretics)
Oral: Initially 5 mg/ day orally (if the patient is not taking diuretics)
Usually, the dosage range is 10 to 40 mg daily as 1 or 2 divided doses.
Parenteral: 0.625-1.25 mg up to 5 mg, intravenously over 5 minutes, every six hours.
Heart failure
Adults and Elderly:
Oral: Initially 2.5 mg once or twice daily. The dose can be increased gradually over 2-4 weeks. The maintenance is 5 to 40 mg daily as two divided doses.
The maximum daily dose is 40 mg in two divided doses.
Left ventricular dysfunction
Adults and Elderly:
Oral: 2.5 mg twice daily. Maintenance dose is 20 mg/day in 2 divided doses
Renal dose adjustment
If CrCl is 30 mL/minute or less:
- Hypertension
Oral: Initially 2.5 mg/day, and then titrated until blood pressure is controlled.
- Heart failure
Oral: Initially 2.5 mg twice daily, then it can be increased by 2.5 mg/dose at greater than 4-day intervals.
The maximum dose is 40 mg/day.
If CrCl is greater than 30 mL/minute:
Usually, no dosage adjustment will be needed.
Hemodialysis:
On dialysis days, initially 2.5 mg; on-dialysis days the dose should be adjusted depending on the blood pressure.
No dose adjustment.
1. Kizior, R.J. and Hodgson, B.B. (2018). Saunders nursing drug handbook 2019. Philadelphia: Saunders.
2. Williams and Wolters Kluwer Health (2012). Nursing 2012 drug handbook. Philadelphia, Pa.: Wolters Kluwer Health/Lippincott Williams & Wilkins.
3. Joint formulary committee, BNF 80 (The British National Formulary), 80th Revised edition, Pharmaceutical Press, London, United Kingdom, [2020]
Click here to read more about the correct way to use this medication and learn about its side effects.
.jpg)
The ureters are tubes that transport urine from the kidneys to the urinary bladder. Urinary bladder is a muscular sac that temporarily stores urine.
Correct diagnosis of a kidney stone has magnificent importance for the treatment and prevention of kidney stones.
.jpg)
This article focuses on the side effects of the drug as well as lisinopril warnings. Click here to read about the most common, common, and rare side effects of this medication.
Dosage guide of Lisinopril: Click to read about the dose for your specific condition and age group.
Subscribe to our email lists and upgrade your life into a healthier and happier one.
SubscribeSign up for our newsletter(s) and receive healthy and scientific content to have a healthier life.
Choose Newsletter(s)Follow Medical Hex on social media platforms to be informed about latest health news and health-related scientific concepts.
A place you can find correct medical advice and information on health conditions as well as medical scientific articles. Our aim is to improve the health of human race by increasing health literacy through providing science-based content about health conditions.
©2022 Medical Hex. All Rights Reserved.