Rabeprazole sodium (Aciphex) is a proton pump inhibitor that acts by reducing the amount of belongs to a group of medicine known as proton pump inhibitors, it acts by reducing the amount of acid that the stomach produces; hence it is used to treat gastroesophageal reflux disease (GERD), peptic ulcer and duodenal ulcers.

Aciphex is the brand name for Rabeprazole, and it is available as Tablets, Capsules and Sprinkle.

Rabeprazole sodium is available as:

Delayed-release Oral Tablets: 20mg

Capsule: 5 mg, 10mg.

Sprinkle: 5mg, 10mg.

For each of the following conditions. The dosage of rabeprazole is as follows:

Gastroesophageal reflux disease (GERD), erosive or ulcerative

For adults:

Orally: Give 20mg daily, for 4 - 8 weeks.

Maintenance dose: 10 - 20mg daily.

For children of 1 to 11 years:

Weighing 15kg and greater: 10mg once daily for 12 weeks.

Weighing less than 15kg: 5 mg once daily for 12 weeks, can be increased to 10 mg daily.

Severe Esophagitis

Adults:

- Orally: Give 20mg daily, for 8 weeks.

Hypersecretory Conditions (Zollinger-Ellison syndrome)

Adults and Elderly:

Orally: initially give 60 mg once daily for 10-14 days. The dose can be increased to 60 mg twice daily.

Duodenal ulcer

20 mg could be taken once a day for 4 weeks, preferably after breakfast.

NSAIDs associated peptic ulcer

20 mg could be taken once a day for 8 weeks.

H. Pylori Infection

Adults and Elderly:

20 mg to be administered twice daily for 10–14 days (with amoxicillin 1,000 mg and clarithromycin 500 mg).

No dose adjustment.

Mild to moderate hepatic impairment:No dose adjustment.

Severe hepatic impairmentthe drug should be used with caution.